What does a trazodone look like

Monographs-Pediatrics. What does TRAZODONE HCL look like? View images of TRAZODONE HCL and identify pills by imprint, color or shape. If you need to save …

What does a trazodone look like. (trazodone hydrochloride) Extended-release Tablets. Read the Medication Guide that comes with Oleptro before you start taking it and each time you get a refill. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or treatment.

Trazodone (Ingredient) Chemical formula: C19H22ClN5O Drugbank ID: DB00656 ATC code: N06AX05. The information below refers to products available in the United States that contain trazodone. Products containing trazodone trazodone systemic. Brand names: Desyrel, Oleptro, Desyrel Dividose Drug class: phenylpiperazine antidepressants

Yes, trazodone comes in liquid form. In its liquid formulation, trazodone hydrochloride is available as an oral solution. Trazodone, an antidepressant, is classified as a serotonin antagonist and reuptake inhibitor (SARI) (1). Trazodone hydrochloride is the salt form of trazodone which is used in medications. Trazodone is available in solid and ...29 Apr 2024 ... Trazodone is the generic name of the drug, which refers to the active ingredient, trazodone hydrochloride, according to the U.S. National ...This drug can cause low sodium levels. Very low sodium levels can be life-threatening, leading to seizures, passing out, trouble breathing, or death. If you are 65 or older, use this drug with care. You could have more side effects. Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding.Trazodone is an antidepressant that is used to treat major depressive disorder. Trazodone may also be used for purposes not listed in this medication guide. ... (like you might pass out); slow heartbeats; unusual thoughts or behavior; easy bruising, unusual bleeding; or; low levels of sodium in the body--headache, confusion, slurred speech ...Naltrexone Pill Images. Note: Multiple pictures are displayed for those medicines available in different strengths, marketed under different brand names and for medicines manufactured by different pharmaceutical companies. Multi-ingredient medications may also be listed when applicable. What does Naltrexone hydrochloride look like?30 Jan 2024 ... What Does Trazodone Look Like? ... Trazodone is typically supplied as a small white tablet, which is scored down the middle. Less commonly, ...

As mentioned before, quitting trazodone can lead to withdrawal effects. Withdrawal symptoms are the result of changes to our brains caused by drugs. Trazodone causes changes in our serotonin receptors. When Trazodone is used, our brain decreases the number of receptors. When a person suddenly stops taking trazodone, the decreased …Jan 15, 2023 · Below is a partial list of mild side effects of trazodone. To learn about other mild side effects, talk with your doctor or pharmacist, or view trazodone’s prescribing information. Mild side ... Pill with imprint 8 05 is White, Round and has been identified as Trazodone Hydrochloride 50 mg. It is supplied by Zydus Pharmaceuticals (USA) Inc. Trazodone is used in the treatment of Depression; Sedation; Major Depressive Disorder and belongs to the drug class phenylpiperazine antidepressants . Risk cannot be ruled out during pregnancy.There are 647 drugs known to interact with trazodone, along with 8 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 136 are major, 496 are moderate, and 15 are minor. Does trazodone interact with my other drugs? Enter other medications to view a detailed report. ...Trazodone tablets come as 50mg, 100mg and 150mg strengths. Capsules come as 50mg and 100mg strengths. The liquid has either 10mg or 20mg of trazodone in every 1ml. For depression, the usual dose is 150mg daily. But in some cases your doctor may start you on a lower dose of 100mg to reduce the chance of side effects.Trazodone Interactions. There are 647 drugs known to interact with trazodone, along with 8 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 136 are major, 496 are moderate, and 15 are minor.Trazodone (Ingredient) Chemical formula: C19H22ClN5O Drugbank ID: DB00656 ATC code: N06AX05. The information below refers to products available in the United States that contain trazodone. Products containing trazodone trazodone systemic. Brand names: Desyrel, Oleptro, Desyrel Dividose Drug class: phenylpiperazine antidepressantsWhat does DICYCLOMINE HCL (Generic for BENTYL) look like? View images of DICYCLOMINE HCL and identify pills by imprint, color or shape. If you need to save money on your DICYCLOMINE HCL, compare our prices. Our prescription savings may even be lower than your insurance copay!

The trazodone dosage for dogs can vary and your veterinarian will advise you on what dose to start with based on your dog’s specific circumstances and size. The dosage range goes from 1.7 to 9.5 mg/kg orally every 8 to 24 hours. Your veterinarian will usually start your dog off at the lower end of the scale and gradually taper them up as needed.Trazodone may also be used to treat other conditions such as problems sleeping, anxiety, and panic attacks. Buy Trazodone Tablets Online - Free Worldwide Shipping Trazodone is an oral state of mind elevator considered depression, anxiety (when it's a sign of misery), in addition to for agoraphobia, panic strikes and boosted aggressiveness.This drug can cause low sodium levels. Very low sodium levels can be life-threatening, leading to seizures, passing out, trouble breathing, or death. If you are 65 or older, use this drug with care. You could have more side effects. Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding.Uses. Trazodone is used to control symptoms of depression, but it cannot cure depression. Your healthcare provider may start you at a low dose and gradually increase it. Trazodone increases serotonin activity in your brain. Serotonin is a chemical that normally promotes a feeling of mental wellbeing.

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Trazodone tablets come as 50mg, 100mg and 150mg strengths. Capsules come as 50mg and 100mg strengths. The liquid has either 10mg or 20mg of trazodone in every 1ml. For depression, the usual dose is 150mg daily. But in some cases your doctor may start you on a lower dose of 100mg to reduce the chance of side effects.Explore the signs and symptoms, genetic cause, and inheritance pattern of various health conditions.Trazodone (Desyrel) received an overall rating of 6 out of 10 stars from 352 reviews. See what others have said about Trazodone (Desyrel), including the effectiveness, ease of use ...What Does Trazodone Look Like? Trazodone is typically supplied as a small white tablet, which is scored down the middle. Less commonly, trazodone may be supplied as a capsule or as a liquid (suspension). How Does Trazodone for Dogs Work? Trazodone provides mild sedation and decreases anxiety in dogs.Maximum dose: 400 mg per at 1-866-832-8537 or Trazodone hydrochloride tablets are available in the following strengths: day in divided doses (2). [email protected]; or 300 mg: White, oval, flat-faced, beveled-edge tablet with one side scored with.

Dec 31, 2015 · Trazodone treats depressed mood and other depression-related symptoms and shows benefit in the treatment of insomnia due to its sedating effects. 20 It is known to prolong the cardiac QT-interval. 21 Memory, alertness, and cognition may be decreased by trazodone, especially in elderly patients due to its central nervous system depressant effects. 9 Trazodone. Brand name: Molipaxin. Find out how trazodone treats depression and anxiety and how to take it. About trazodone. Who can and cannot take it. How and when to take it. Side effects. Pregnancy, breastfeeding and fertility. Taking trazodone with other medicines and herbal supplements. Trazodone. Brand name: Molipaxin. Find out how trazodone treats depression and anxiety and how to take it. About trazodone. Who can and cannot take it. How and when to take it. Side effects. Pregnancy, breastfeeding and fertility. Taking trazodone with other medicines and herbal supplements. Research. Veterinary use. See also. References. External links. Trazodone, sold under many brand names, [1] is an antidepressant medication. [20] . It is used to treat major …Aug 5, 2019 · In 1981, trazodone (the generic name of the pharmaceutical) was approved by the U.S. Food and Drug Administration (FDA) under the brand name Desyrel for use in treating major depressive disorder. Today, the medication is prescribed under the brand name Oleptro to treat sleep disorders such as insomnia as well as anxiety disorder and unipolar ... Find out how to improve your kitchen on a budget by refinishing plastic laminate countertops, replacing the range hood, and installing insulating window film. Expert Advice On Impr... Constipation. continuing ringing or buzzing or other unexplained noise in the ears. diarrhea. hearing loss. muscle aches or pains. weight loss. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. FDA-approved Indications. Trazodone is an FDA-approved antidepressant for treating major depressive disorders. [1] . It can be used as part of combination therapy with other drugs or psychotherapies or … unusual bruising or bleeding. nosebleeds. small red or purple dots on the skin. erection lasting more than 6 hours. headache. problems with thinking, concentration, or memory. weakness. problems with coordination. Trazodone can cause painful, long lasting erections in males. The Tarrant County Medical Examiner’s Office has ruled combined toxicity of the drugs fentanyl and trazodone — an antidepressant and sedative — was the cause of …Trazodone tablets come as 50mg, 100mg and 150mg strengths. Capsules come as 50mg and 100mg strengths. The liquid has either 10mg or 20mg of trazodone in every 1ml. For depression, the usual dose is 150mg daily. But in some cases your doctor may start you on a lower dose of 100mg to reduce the chance of side effects.TME: Get the latest Tencent Music Entertainment Group stock price and detailed information including TME news, historical charts and realtime prices. Indices Commodities Currencies...

Go to: This study evaluated the effect of 3 doses of a trazodone hydrochloride 6% oral drops solution on the QT interval of healthy volunteers. Subjects were randomly assigned to receive a single dose of trazodone 20 mg, 60 mg, and 140 mg, moxifloxacin 400 mg, and trazodone‐matched placebo in 5 periods separated by 7‐day …

Atlassian introduces AI-driven virtual teammate, Atlassian Intelligence, that brings together Atlassian's own model and OpenAI's tools. Atlassian today announced the launch of Atla...Thankfully, trazodone is a short-acting drug, meaning that the side effects are usually mild and quick to improve. If your dog shows any signs of being unwell while taking trazodone, you should speak to your veterinarian. Possible side effects of trazodone include: Sedation or drowsiness. Panting.The trazodone dosage for dogs can vary and your veterinarian will advise you on what dose to start with based on your dog’s specific circumstances and size. The dosage range goes from 1.7 to 9.5 mg/kg orally every 8 to 24 hours. Your veterinarian will usually start your dog off at the lower end of the scale and gradually taper them up as …However, many people have no side effects or only have minor side effects. Call your child’s doctor or get medical help if any of these side effects or any other side effects bother your child or do not go away: Feeling dizzy, sleepy, tired, or weak. Constipation, diarrhea, stomach pain, upset stomach, or throwing up. Dry mouth.Trazodone side effects. There are several side effects associated with trazodone use, ranging from mild to severe. Those who use trazodone may expect to experience some of the more mild side effects of the drug, with most symptoms dissipating over time. Some of the common side effects of trazodone include: Swelling. Sleepiness.Lanna Apisukh for The New York Times. By Siobhan Burke. May 7, 2024. Bill T. Jones still remembers warming up backstage for one of his first New York City …Trazodone has severe interactions with at least 17 other drugs. Trazodone has serious interactions with at least 124 other drugs. Trazodone has moderate interactions with at least 415 other drugs. Trazodone has minor interactions with at least 137 other drugs. This information does not contain all possible interactions or adverse effects.

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Tramadol Pill Images. Note: Multiple pictures are displayed for those medicines available in different strengths, marketed under different brand names and for medicines manufactured by different pharmaceutical companies.The withdrawal period can vary in length from one week to four weeks. Most often, it is brief. Symptoms that occur as a result of withdrawal from trazodone are typically mild compared to other withdrawal syndromes (e.g., withdrawal from alcohol, pain medications, benzodiazepines, etc.), and the symptoms appear to mimic a mild case of influenza.For trazodone hydrochloride. Withdrawal effects may occur within 5 days of stopping treatment with antidepressant drugs; they are usually mild and self-limiting, but in some cases may be severe. The risk of withdrawal symptoms is increased if the antidepressant is stopped suddenly after regular administration for 8 weeks or more.Trazodone, sold under many brand names, [1] is an antidepressant medication. [20] It is used to treat major depressive disorder, anxiety disorders, and insomnia. [20] The medication is taken orally. [20] Common side effects include dry mouth, feeling faint, vomiting, and headache. [20]Trazodone drug interactions can range from mild discomfort to life-threatening conditions, so using it as it was intended is essential. Some of the most dangerous interactions that trazodone has are with: Nonsteroidal anti-inflammatory drugs (NSAIDs) Medications that increase serotonin levels. Blood thinners.Yes, trazodone comes in liquid form. In its liquid formulation, trazodone hydrochloride is available as an oral solution. Trazodone, an antidepressant, is classified as a serotonin antagonist and reuptake inhibitor (SARI) (1). Trazodone hydrochloride is the salt form of trazodone which is used in medications. Trazodone is available in solid and ...Japanese packaging for a form of trazodone. If you use trazodone to alleviate insomnia and suddenly discontinue use, you might experience symptoms like anxiety, irritability, depression and mild flu …Oct 14, 2022 · Trazodone is a prescription drug used to treat depression and sleep disorders like insomnia. When using trazodone for sleep, the drug is given at low doses—typically between 25 to 100 milligram (mg)—which reduces the risk of drug tolerance and daytime sleepiness. For some people, even lower doses may prove effective and cause fewer side ... Dosage and Administration. According to the appropriate trazodone summary of product characteristics (SPC) [31–33], therapy should begin with an evening administration (starting dose 75–150 mg before bedtime).Subsequently, the dose can be increased every 3 days up to 300 mg/day, to be administered in repeated doses after …Trazodone is a prescription drug used to treat depression and sleep disorders like insomnia.When using trazodone for sleep, the drug is given at low doses—typically between 25 to 100 milligram (mg)—which reduces the risk of drug tolerance and daytime sleepiness. For some people, even lower doses may prove …what does 50 mg trazodone look like trazodone insomnia dose. Search for: This topic has 0 replies, 1 voice, and was last updated 1 week, 4 days ago by Shalonda. Viewing 1 post (of 1 total) Author. Posts. April 14, 2024 at 9:49 pm #602380. Shalonda. Participant. Pharmacie européenne .6 Dec 2021 ... You should look up the uses of Trazadone befor you do anything. ... How does trazodone ... would produce pages that look like I had become possessed ... ….

Pill with imprint PLIVA 433 is White, Round and has been identified as Trazodone Hydrochloride 50 mg. It is supplied by Major Pharmaceuticals. Trazodone is used in the treatment of Depression; Sedation; Major Depressive Disorder and belongs to the drug class phenylpiperazine antidepressants . Risk cannot be ruled out during pregnancy.Second Phase (Days 3-5) Like most drugs, the second phase is the most intense as symptoms tend to peak and then gradually fade. During this time, individuals can experience dizziness, nausea, shakiness, and fever. If a person has taken trazodone in high doses for long periods, the symptoms will be more intense.Trazodone can be lethal if more then the prescribed dose is taken, but instances are rare, according to MedlinePlus. The average dose for an outpatient adult ranges from 150 millig...Suboxone Pill Images. Note: Multiple pictures are displayed for those medicines available in different strengths, marketed under different brand names and for medicines manufactured by different pharmaceutical companies. Multi-ingredient medications may also be listed when applicable.The trazodone dosage for dogs can vary and your veterinarian will advise you on what dose to start with based on your dog’s specific circumstances and size. The dosage range goes from 1.7 to 9.5 mg/kg orally every 8 to 24 hours. Your veterinarian will usually start your dog off at the lower end of the scale and gradually taper them up as needed.Trazodone, Oral Tablet. Trazodone is a generic drug that doctors may prescribe to treat depression. Side effects are usually mild, but possible serious side effects include rapid heart rate ...4. Ramelteon. Ramelteon (Rozerem) is a melatonin antagonist and may help a person fall asleep. Melatonin is a naturally occurring substance in the body, and by affecting melatonin receptors ...Trazodone (traz' oh done) is a triazolopyridine derivative whose mechanism of action is believed to be inhibition of serotonin reuptake and modulation of serotonin receptor activity, which results in increased levels and activity of serotonin. Trazodone was approved for use in major depressive disorder in the United States in 1981 and remains ...Trazodone is an inexpensive drug used to treat depression. This drug is more popular than comparable drugs. Trazodone is only available as a generic drug; all brands have been discontinued. Generic trazodone is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. Get trazodone for as low as …The American College of Physicians also does not recommend trazodone in its 2021 insomnia treatment guidelines. And a May 2018 Cochrane review found that there’s no good evidence to support the ... What does a trazodone look like, Trazodone works by helping to restore the balance of a certain natural chemical (serotonin) in the brain. HOW TO USE: Read the Medication Guide provided by your pharmacist before you start using trazodone and each time you get a refill. If you have any questions, consult your doctor or pharmacist.Take this medication by mouth, usually once or ..., There are 647 drugs known to interact with trazodone, along with 8 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 136 are major, 496 are moderate, and 15 are minor. Does trazodone interact with my other drugs? Enter other medications to view a detailed report. ..., This medication does not contain gluten or tartrazine. How should I use this medication? The recommended adult dose of trazodone ranges from 150 mg to 300 mg daily, taken in 2 or 3 divided doses with a meal or light snack. The dose is usually started at 150 mg to 200 mg daily and increased gradually until the best dose is found., Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. phenytoin. trazodone increases levels of phenytoin by unspecified interaction mechanism., This drug can cause low sodium levels. Very low sodium levels can be life-threatening, leading to seizures, passing out, trouble breathing, or death. If you are 65 or older, use this drug with care. You could have more side effects. Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding., Jul 25, 2022 · Trazodone Images. See image of Trazodone for shape, color, size and other Bipolar Disorder drugs at CVS, Walgreens, and other nearby pharmacies. , Trazodone overdose can occur when a person takes too much trazodone at one time. Signs and symptoms of an overdose may include excessive drowsiness, low blood pressure, fainting, or an irregular heartbeat. When trazodone is taken with other medications that affect serotonin levels, a severe and sometimes fatal condition called serotonin ... , Olanzapine Pill Images. Note: Multiple pictures are displayed for those medicines available in different strengths, marketed under different brand names and for medicines manufactured by different pharmaceutical companies. Multi-ingredient medications may also be listed when applicable. What does Olanzapine look like?, In addition, trazodone is sometimes prescribed off-label for difficulty sleeping (insomnia). This medication is taken by mouth, typically once or a few times a day, depending on your condition. Common side effects of this medication include sleepiness, dry mouth, and dizziness. Brand name Desyrel has been discontinued., The serotonin effects of trazodone occur within half an hour of taking a dose, so side effects such as drowsiness, dry mouth, dizziness, trouble sleeping, nausea, urinary incontinence, blurred vision, genital numbing, and similar side effects are sometimes experienced early or even after the first dose. Other side effects, such as sexual ..., Pill with imprint 13 30 is White, Round and has been identified as Trazodone Hydrochloride 50 mg. It is supplied by Torrent Pharmaceuticals Limited. Trazodone is used in the treatment of Depression; Sedation; Major Depressive Disorder and belongs to the drug class phenylpiperazine antidepressants . Risk cannot be ruled out during pregnancy., Like a lot of medications, trazodone does carry a risk of side effects in dogs. You won’t find many – or any, more likely – that don’t have the potential for side effects. With trazodone, the most common side effects include drowsiness; it is a sedative, after all, so a little sleepiness is to be expected., One Minute Money: Simply paying bills on time is one way to help raise your credit score, explains Kristen Bellstrom. By clicking "TRY IT", I agree to receive newsletters and promo..., May 24, 2019 · Like many antidepressants, trazodone has been issued a “Black Box Warning” by the FDA. Taking trazodone has increased the risk of suicidal thoughts and behaviors in pediatric and young adult ... , Nov 6, 2022 · Antidepressants like trazodone are used to ease symptoms such as low mood, poor sleep and poor concentration. This in turn allows you to function more normally and cope better with any difficult circumstances. Trazodone also helps to reduce the symptoms of anxiety, even if you are not depressed. , WebMD. ). Trazodone is an FDA-approved medication to treat depression, although it has also been used to treat anxiety and insomnia. The drug's side effects can make you …, Trazodone. Trazodone is used for treating depression. It may also be used for relief of an anxiety disorder (e.g., sleeplessness, tension), chronic pain. Trazodone (brand names Desyrel, Molipaxin, Deprax, Trittico, Thombran, Trialodine, Trazorel) is a psychoactive compound with sedative, anxiolytic, and antidepressant properties., Trazodone, Oral Tablet. Trazodone is a generic drug that doctors may prescribe to treat depression. Side effects are usually mild, but possible serious side effects include rapid heart rate ..., Molipaxin ®. Available as. Capsules, tablets and liquid medicine. Depression and anxiety can develop for no apparent reason, or they may be triggered by a life event such as a relationship problem, bereavement, or illness. Antidepressants like trazodone are used to ease symptoms such as low mood, poor sleep and poor concentration., What Does Trazodone Look Like? Trazodone comes in different pill shapes, colors, and dosages from different brands. The 8 05 pill is usually white and comes in round tablets, but you may see oval, rectangular, or other pill shapes., Trazodone is a serotonin reuptake inhibitor (SSRI). This is commonly used to treat anxiety and depression or help with storm phobias. Trazodone works in the brain by keeping serotonin in the brain’s synaptic space for a longer time. Serotonin is responsible for your dog feeling good. This will help make your dog happier and stress-free., TRAZODONE (TRAZ oh done) treats depression. It increases the amount of serotonin in the brain, a hormone that helps regulate mood. ... Bleeding—bloody or black, tar-like stools, red or dark brown urine, vomiting blood or brown material that looks like coffee grounds, small, red or purple spots on skin, unusual bleeding or bruising; Heart ..., Constipation. continuing ringing or buzzing or other unexplained noise in the ears. diarrhea. hearing loss. muscle aches or pains. weight loss. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects., Trazodone Pill Images. Note: Multiple pictures are displayed for those medicines available in different strengths, marketed under different brand names and for medicines manufactured by different pharmaceutical companies. Multi-ingredient medications may also be listed when applicable. What does Trazodone hydrochloride look like?, Trazodone is an antidepressant. It is also known by the trade name Molipaxin. You can find detailed information about this drug in the official Patient Information Leaflet (PIL). This includes information on what the medication is for, how to take it, possible side effects and safety information. This leaflet should come with your medication ..., White. While they may come in different shapes or be made by different pharmaceutical companies, the most common color of pure hydrocodone and combination hydrocodone pills is white. Norco is a popular brand name for the combination of hydrocodone and acetaminophen. The white pill has a dosage of 7.5 mg of hydrocodone and 325 mg of …, For trazodone hydrochloride. Withdrawal effects may occur within 5 days of stopping treatment with antidepressant drugs; they are usually mild and self-limiting, but in some cases may be severe. The risk of withdrawal symptoms is increased if the antidepressant is stopped suddenly after regular administration for 8 weeks or more., Pharmacology. Pictures. Resources. TRAZODONE (tablet) can come in different packaging based on the dosage and strength of the medication. Below are pictures of Trazodone …, what does 50 mg trazodone look like trazodone insomnia dose. Search for: This topic has 0 replies, 1 voice, and was last updated 1 week, 4 days ago by Shalonda. Viewing 1 post (of 1 total) Author. Posts. April 14, 2024 at 9:49 pm #602380. Shalonda. Participant. Pharmacie européenne ., Trazodone (brand name Desyrel®, Oleptro®) is a serotonin antagonist/reuptake inhibitor (SARI) antidepressant that is used to treat behavioral disorders, especially anxiety- or phobia-related in dogs (e.g., separation anxiety, noise phobia such as fireworks or thunderstorms, veterinary visits, hospitalization, and travel)., Updated May 11, 2024 at 9:52 p.m. EDT | Published May 10, 2024 at 3:23 p.m. EDT. The northern lights, formerly known as aurora borealis, appeared in the early …, Trazodone has alpha-1 adrenergic blocking activity and may cause hypotension (including orthostatic hypotension) in approximately 5% of patients. Therapy with trazodone should be administered cautiously in patients with hypotension or conditions that could be exacerbated by hypotension, such as a history of myocardial infarction, angina, or ..., Trazodone Hydrochloride Tablets are indicated for the treatment of major depressive disorder (MDD) in adults. 2 DOSAGE AND ADMINISTRATION. 2.1 Dose Selection - An initial dose of 150 mg/day in divided doses is suggested. The dosage should be initiated at a low-dose and increased gradually, noting the clinical response and any ...