Lapine s-100b immune globulin

The active ingredient in Brillia is Lapine S-100B immune globulin, an antibody specific to the S-100B protein that is present in the brain.

RAGE is highly expressed in lung by Alveolar Type-I (AT-I) cells and its activation contributes to ALI/ARDS pathogenesis. In this in-vitro study, we tested the hypothesis that S100B stimulates an ATI-derived cell line (R3/1) to secrete inflammatory mediators involved in lung inflammation. Our main result is that S100B stimulates R3/1 cells to ...GSRS - National Institutes of Health LAPINE S-100 IMMUNE GLOBULIN is a substance that contains antibodies derived from rabbits. It is used in some homeopathic products to treat various symptoms related to anxiety, stress, irritability, and attention. Learn more about its structure, properties, and sources on this webpage.Circulating S100B is taken up by peripheral immune cells. AlexaFlour 488-tagged S100B protein accumulated in Langerhans cells of the skin (A1, 2), thymic dendritic cells (B1, 2), and in dendritic cells in lymph nodes (a para-aortic lymph node is shown in C1, 2). Note the lack of uptake by non-immune surrounding tissue.What is immune globulin? Immune globulin subcutaneous (for injection under the skin) is used to treat primary immunodeficiency diseases. Immune globulin is also used to treat chronic inflammatory demyelinating polyneuropathy (an autoimmune disorder in which the immune system attacks the nerves, causing muscle weakness and …BRILLIA HEALTH COUGH CONTROL (lapine bradykinin immune globulin (12c, 30c, 50c), lapine morphine immune globulin (12c, 30c, 50c), lapine histamine immune globulin- 12c, 30c, 50c tablet If this SPL contains inactivated NDCs listed by the FDA initiated compliance action, they will be specified as such.HepaGam B, Hepatitis B Immune Globulin Intravenous (Human), is a solvent/detergent-treated sterile solution of purified gamma globulin containing anti-HBs. It is prepared from plasma donated by healthy, screened donors with high titers of anti-HBs that is purified by an anion-exchange column chromatography manufacturing method 9,10 .LAPINE BRADYKININ IMMUNE GLOBULIN FX59DZ02OS Other Approval Year Unknown. 134361. Substance Class: Structurally Diverse Created. by admin. on Thu Jul 06 21:38:34 UTC 2023. Edited. by admin. on Thu Jul 06 21:38:34 UTC 2023. Source Materials Class: ORGANISM: Source Materials Type: MAMMAL: Source Materials Parent ...

Lapine S-100 immune globulin chemical information summary.I. IMMUNE GLOBULIN (IG) FOR THE PROPHYLAXIS OF MEASLES*. Immune globulin should be administered <6 days of last exposure to measles. IG intramuscular (IM) or IG intravenous (IV) may be used depending on recipient. Use formulation and dosage according to recipient's category in Section II. There is only one IGIM product in the U.S. (GamaSTAN®).Lapine S-100 immune globulin How It Works Lapine S-100 are antibodies that bind to the S100B protein to help regulate their activity and reduce the symptoms of hyperactivity and irritability.Gamma globulins (also called immunoglobulins) help the immune system fight off foreign substances and infections. Providers use this globulin test to diagnose conditions that affect the immune system, such as: Allergies. Autoimmune diseases like lupus and rheumatoid arthritis. Multiple myeloma. Waldenstrom's macroglobulinemia.Active Ingredient: Lapine S-100 immune globulin mixture of homeopathic dilutions 12C, 30C and 50C. Brillia is a unique combination of antibody science and homeopathic formulation. The active ingredient of Brillia is antibodies to the brain-specific S100 protein (S100B). This protein is an important regulator of many different …Rabies IG doses within 10% of the recommended 20 IU/kg dose were considered appropriate, as orders for some medications (e.g., immune globulin and high-cost medications) can be rounded to the nearest vial size if the rounded dose is within 10% of the calculated dose. 6, 23 - 25 Investigators attempted to identify the cause of inappropriate ...

Korfias S, Stranjalis G, Papadimitriou A, Psachoulia C, Daskalakis G, Antsaklis A, et al. Serum S-100B protein as a biochemical marker of brain injury: a review of current concepts. Curr Med Chem. 2006; 13 (30):3719-3731. doi: 10.2174/092986706779026129. [Google Scholar] 14. Papa L, Silvestri S, Brophy GM, Giordano P, Falk JL, Braga CF, et al ...Brillia contains three active ingredients, all of which are different potencies of a compound called Lapine S-100 immune globulin. We cannot find any clinical studies published in peer-reviewed medical journals proving the safety or efficacy of this ingredient. Brillia describes this ingredient as "antibodies to the brain-specific S100 ...BRILLIA HEALTH COUGH CONTROL (lapine bradykinin immune globulin (12c, 30c, 50c), lapine morphine immune globulin (12c, 30c, 50c), lapine histamine immune globulin- 12c, 30c, 50c tablet If this SPL contains inactivated NDCs listed by the FDA initiated compliance action, they will be specified as such.Administration. Give Hepatitis B immune globulin at the same time or up to 1 mo preceding hepatitis B vaccination (hepatitis B vaccine) does not impair the active immune response from the vaccination. Give preferably into deltoid muscle or anterolateral aspect of thigh. Note: For neonates and small children the preferred injection site is the ...<link rel="stylesheet" href="styles.954869108174c63c.css"> <link rel="stylesheet" href="/assets/styles/styles.custom.css">

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noun. : globulin from the blood of a person or animal immune to a particular disease. called also immune serum globulin.Label: BRILLIA HEALTH COLD-FLU RECOVERY (lapine histamine immune globulin (12c, 30c, 50c), lapine interferon gamma immune globulin (12c, 30c, 50c), lapine cd4 immune globulin- 12c, 30c, 50c tabletSHRI NAGNATH KIRANA is located in Bhankheda, Hingoli. Currently we do not have any reviews or rating for SHRI NAGNATH KIRANA. There are at least 3 Indian grocery stores in Bhankheda, out of which this Indian grocery store has an overall rank of 2. Address of the Indian grocery store is SINGI NAGA, Sengaon, Maharashtra 431542.Label: BRILLIA- lapine s-100 immune globulin 12 hpc, 30 hpc, 50 hpc pill. Label RSS; Share Bookmark & Share. View Package Photos ...PubMed

Feb 18, 2023 · Brillia contains three active ingredients, all of which are different potencies of a compound called Lapine S-100 immune globulin. We cannot find any clinical studies published in peer-reviewed medical journals proving the safety or efficacy of this ingredient. Brillia describes this ingredient as “antibodies to the brain-specific S100 ... <link rel="stylesheet" href="styles.954869108174c63c.css"> <link rel="stylesheet" href="/assets/styles/styles.custom.css">Label: BRILLIA- lapine s-100 immune globulin 12 hpc, 30 hpc, 50 hpc pillUNII A4FH976KAQ LAPINE S-100 IMMUNE GLOBULIN. Unique Ingredient Identifier A4FH976KAQ is listed as a ingredient substanceAdditionally, we did not find any significant correlation between S100b levels and NIHSS on admission (Spearman's rho = 0.213, P = 0.058), or age (Spearman's rho = −0.120, P = 0.290). The different types of hemorrhagic transformation observed and S100b expression in extracted thrombus material is described in Supplementary Table 1 .The NDC code 72126-007 is assigned by the FDA to the product Tegsedi which is a human prescription drug product labeled by Akcea Therapeutics, Inc.. The generic name of Tegsedi is inotersen. The product's dosage form is injection, solution and is administered via subcutaneous form. The product is distributed in a single package with assigned ...Wondering what to do with your vaccination card until it’s time to travel? Here's what we know. As you may know if you've already been vaccinated, the only way to confirm that some...Information was collected from the parent about the child's behaviour relating to 4 domains: mood disorder, ADHD/hyperkinetic disorder, disruptive behaviour and additional problems. Parents describe their child's behaviour in unstructured (e.g. playing alone), semi-structured (e.g. meal times) and structured (e.g. homework) daily life situations.

S-100 protein (S-100B) is the most widely used marker for peripheral nerve sheath tumors. Although S-100 protein is positive in all benign Schwann cell tumors, this marker shows relatively low sensitivity for MPNST (at most, around 50%). Because S-100 protein is also expressed in a variety of other cell types, a range of other tumors are also ...

Flushing, headache, dizziness, chills, muscle cramps, back/ joint pain, fever, nausea, or vomiting may occur. Tell your doctor or other health care professional right away if any of these effects ...BRILLIA ADULT- lapine s-100 immune globulin pill Hadaf LLC. Disclaimer: This homeopathic product has not been evaluated by the Food and Drug Administration for safety or efficacy. FDA is not aware of scientific evidence to support homeopathy as effective.National Cancer Institute. Lapine T-Lymphocyte Immune Globulin. NCI Thesaurus. Code C80833. A preparation of purified, pasteurized, gamma globulin obtained by the immunization of rabbits with human thymocytes, with T-cell depleting and immunosuppressive activities. Upon administration, rabbit anti-thymocyte globulin (rATG) specifically recognizes,[Validation]WARNING:Substance LAPINE HISTAMINE IMMUNE GLOBULIN (ID: 1bb6a4f5-bc51-150f-88f7-c6b973cf... Show all : View [Validation]WARNING:Substance LAPINE INTERFERON GAMMA IMMUNE GLOBULIN (ID: fb776bb7-a14a-bc77-c6fe-a... Show all : View: References. Search. Show Filter. Citation . Type . Tags . File . Access . Citation Filter.Lapine S-100 immune globulin chemical information summary.Gamma globulins (also called immunoglobulins) help the immune system fight off foreign substances and infections. Providers use this globulin test to diagnose conditions that affect the immune system, such as: Allergies. Autoimmune diseases like lupus and rheumatoid arthritis. Multiple myeloma. Waldenstrom's macroglobulinemia.DrugBank. Lapine t-lymphocyte immune globulin is an Immunoglobulin G. The mechanism of action of lapine t-lymphocyte immune globulin is as an Antibody-Surface Protein Interaction. The physiologic effect of lapine t-lymphocyte immune globulin is by means of Lymphocyte Function Alteration, and Increased T Lymphocyte Destruction. FDA Pharm Classes.Active ingredients include: Lapine S-100 immune globulin, 12C, 30C, and 200C; Inactive ingredients include: Lactose monohydrate, magnesium stearate, Microcrystalline cellulose; Healthcare Conditions Treated by Brillia Brillia’s supplements are formulated to treat anxiety, stress, and ADD/ADHD in both children and adults.

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any words all words exact phrase advanced Advanced search can include the following: • OR operator: | • NOT operators: - OR ! • phrase search: "breast cancer" • AND is implied so listing two words without another operator will search for records where both words are present. • use to group words together:A preparation of purified, pasteurized, gamma globulin obtained by the immunization of rabbits with human thymocytes, with T-cell depleting and immunosuppressive activities. Upon administration, rabbit anti-thymocyte globulin (rATG) specifically reco...NDC Proprietary Name Non-Proprietary Name Dosage Form Route Name Company Name Status; 72123-006: Proprietary Name: Brillia Health Cold-flu Recovery Lapine Histamine Immune Globulin (12c, 30c, 50c), Lapine Interferon Gamma Immune...<link rel="stylesheet" href="styles.954869108174c63c.css"> <link rel="stylesheet" href="/assets/styles/styles.custom.css">Abstract. Rh immune globulin (RhIg) is a human plasma-derived product consisting of IgG antibodies to the D antigen. It is used to prevent immunization to the D antigen in D-negative individuals and for the treatment of immune thrombocytopenia. Each dose of RhIg suppresses the immune response for up to a certain amount of D-positive red blood ...PubMedproducts"), labeled as containing various dilutions of Lapine S-100 immune globulin as active ingredients, to treat diseases or conditions in humans, including attention deficit/hyperactivity ...Rh o (D) Immune Globulin (Human) — Hyper RHO ® S/D Mini-Dose treated with solvent/ detergent is a colorless to pale yellow or pink sterile solution of immune globulin containing antibodies to Rh o (D) for intramuscular administration; it is preservative-free, in a latex-free delivery system. Hyper RHO S/D Mini-Dose is prepared by cold ethanol fractionation from human plasma.BRILLIA- lapine s-100 immune globulin 12 hpc, 30 hpc, 50 hpc pill Out of scope - Out of scope for RxNorm and will not receive RxNorm normal forms. Out of scope information includes radiopharmaceuticals, contrast media, herbals, homeopathics, and food.S100B is a useful neurobiochemical marker of brain damage such as in circulatory arrest, stroke and traumatic brain injury. S100B is also associated with neurodegenerative diseases like Alzheimer's disease or other chronic neurological diseases. Moreover, S100B may have a potential in predicting the efficiency of treatment and prognosis.BRILLIA HEALTH COUGH CONTROL (lapine bradykinin immune globulin (12c, 30c, 50c), lapine morphine immune globulin (12c, 30c, 50c), lapine histamine immune globulin- 12c, 30c, 50c tablet If this SPL contains inactivated NDCs listed by the FDA initiated compliance action, they will be specified as such.UNII: A4FH976KAQ. Preferred Substance Name: LAPINE S-100 IMMUNE GLOBULIN. Synonyms and Mappings. HUMAN S-100 IMMUNE GLOBULIN RABBIT. Resources. … ….

Active Ingredient: Lapine S-100 immune globulin mixture of homeopathic dilutions 12C, 30C and 50C. Brillia is a unique combination of antibody science and homeopathic …Description of Procedure or Service. This policy addresses the use of human immune globulin therapy for preventing and/or treating a wide variety of disorders in the outpatient setting. Both intravenous infusion (IVIg) and subcutaneous infusion (SCIg) of immune globulin are addressed.Anti-D Immune Globulin. Anti-D immune globulin was approved by the Food and Drug Administration (FDA) for the treatment of immune thrombocytopenia in nonsplenectomized Rh-positive patients in 1995. 20 Prepared from the plasma of immunized Rh-negative human donors, it can be used as an alternative to conventional IVIG for patients who have an Rh ...The globulins are a family of globular proteins that have higher molecular weights than albumins and are insoluble in pure water but dissolve in dilute salt solutions. Some globulins are produced in the liver, while others are made by the immune system. Globulins, albumins, and fibrinogen are the major blood proteins.The normal concentration of globulins in human blood is about 2.6-3.5 g/dL.LAPINE HISTAMINE IMMUNE GLOBULIN: Source: Common Name English Code System Code Type Description; DAILYMED: Source: 7U4T47R0DD. Created by admin on Sun Dec 18 18:03:54 UTC 2022, Edited by admin on Sun Dec 18 18:03:54 UTC 2022. PRIMARY FDA UNII: 7U4T47R0DD ...Globulin is a collective term for all the proteins other than albumin in your blood. Albumin makes up about 60% of the total protein. The remaining 40% of proteins in the blood plasma are referred to as globulins. Globulins are comprised of hundreds of different types. Globulins include enzymes, antibodies, hormones, carrier proteins, and ...LAPINE S-100 IMMUNE GLOBULIN edit in new tab. A4FH976KAQ. MYCOBACTERIUM MICROTI IMMUNOSERUM RABBIT edit in new tab. 3ZQN4Y38QI. ORYCTOLAGUS CUNICULUS ANKLE JOINT edit ...Discover expert tips and tricks on Updating Your Local DrugBank Data Read GuideThe effect of S 100B on protein phosphorylation was investigated in a cytoskeletal fraction prepared from immature rat hippocampus. An inhibitory effect of 5 microM S100B on total protein phosphorylation, ranging from 25% to 40%, was observed in the presence of Ca2+ alone, Ca2+ plus calmodulin or Ca2+ plus cAMP. Lapine s-100b immune globulin, Nov 29, 2021 · The active ingredient within Brillia is Lapine S-100B immune globulin, which helps regulate the naturally occurring S-100B protein in the brain. Inactive ingredients include: lactose... , Popular Brands: : Thymoglobulin, Lapine T-lymphocyte Immune Globulin Official FDA Reports 17,102. Social Media Events 0. Total Posts 0. Avg. Review Score 0.00 / 5. Active Ingredients. Lapine T-lymphocyte Immune Globulin; Approved Uses * Immunosuppression; Renal transplant; Transplant * Extracted from Drug Label., Brillia (Children's) Active ingredients Lapine S-100 immune globulin 12C, 30C, and 50C Inactive Ingredients Lactose monohydrate, Magnesium stearate, Microcrystaline cellulose Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away. Uses reduce feelings of anxiety, excitability, and stress, The generic name of Brillia is lapine s-100 immune globulin 12 hpc, 30 hpc, 50 hpc. The product's dosage form is pill and is administered via oral form. The product is distributed in a single package with assigned NDC code 72123-002-01 3 blister pack in 1 box / 20 pill in 1 blister pack., Rho (D) immune globulin (RhIG) is a medication used to manage and treat Rh-negative pregnancies and immune thrombocytopenic purpura. It is in the immune globulin biological class of drugs. This activity reviews the indications, action, and contraindications for RhIG as a valuable agent in managing RhIG in preventing hemolytic disease of the ..., BRILLIA- lapine s-100 immune globulin 12 hpc, 30 hpc, 50 hpc pill Hadaf LLC Disclaimer: This homeopathic product has not been evaluated by the Food and Drug Administration for safety or efficacy. FDA is not aware of scientific evidence to support homeopathy as effective.-----Brillia (Children's) Active ingredients , Each single-dose 10 mL vial contains 25 mg of anti-thymocyte globulin (rabbit), 50 mg glycine, 10 mg sodium chloride, and 50 mg mannitol. After reconstitution with 5 mL SWFI, each vial of reconstituted product contains approximately 5 mg/mL of THYMOGLOBULIN, of which >90% is rabbit gamma immune globulin (IgG)., SEARCH RESULTS for: IMMUNE GLOBULIN (63 results) Share, Brillia is marketed as a holistic treatment; the manufacturer promotes guidelines for proper nutrition, adequate sleep, mindfulness, and controlled screen time along with use of their supplement. The tablet comprises a Lapine S-100 immune globulin mixture of homeopathic dilutions 12C, 30C, and 50C., Administration. Give Hepatitis B immune globulin at the same time or up to 1 mo preceding hepatitis B vaccination (hepatitis B vaccine) does not impair the active immune response from the vaccination. Give preferably into deltoid muscle or anterolateral aspect of thigh. Note: For neonates and small children the preferred injection site is the ..., LAPINE S-100 IMMUNE GLOBULIN A4FH976KAQ Other General Names 2: Identifiers 2: Related Substances 1: LAPINE S-100 IMMUNE GLOBULIN A4FH976KAQ Other Approval Year Unknown. 134361. Name Type Language; LAPINE S-100 IMMUNE GLOBULIN: Source: Common Name English HUMAN S-100 IMMUNE GLOBULIN RABBIT ..., Rabies Immune Globulin Description. Rabies Immune Globulin (Human) USP, Heat Treated, Imogam ® Rabies - HT, is a sterile solution of antirabies immunoglobulin (10-16% protein) for wound infiltration and intramuscular administration. Rabies immune globulin (RIG) is prepared by cold alcohol fractionation from pooled venous plasma of individuals immunized with Rabies Vaccine prepared from ..., What is immune globulin? Immune globulin subcutaneous (for injection under the skin) is used to treat primary immunodeficiency diseases. Immune globulin is also used to treat chronic inflammatory demyelinating polyneuropathy (an autoimmune disorder in which the immune system attacks the nerves, causing muscle weakness and …, BRILLIA HEALTH COLD-FLU RECOVERY (lapine histamine immune globulin (12c, 30c, 50c), lapine interferon gamma immune globulin (12c, 30c, 50c), lapine cd4 immune globulin- 12c, 30c, 50c tablet If this SPL contains inactivated NDCs listed by the FDA initiated compliance action, they will be specified as such., [Validation]WARNING:Substance LAPINE HISTAMINE IMMUNE GLOBULIN (ID: 1bb6a4f5-bc51-150f-88f7-c6b973cf... Show all : View [Validation]WARNING:Substance LAPINE INTERFERON GAMMA IMMUNE GLOBULIN (ID: fb776bb7-a14a-bc77-c6fe-a... Show all : View: References. Search. Show Filter. Citation . Type . Tags . File . Access . Citation Filter., The total serum protein test can be performed to measure the protein levels in the blood and determine if a patient is suffering from a protein deficiency, states WebMD. Globulin i..., Immune Globulin Infusion, 10% (Human) can be administered through the same subcutaneous needle set within approximately 10 minutes after the rHuPH20 infusion is completed. Patients with body weight of 40 kg or above. The Immune Globulin Infusion 10% (Human) should be infused at an initial rate of 10 mL per hour per infusion site., U.S. National Library of Medicine. REPORT ADVERSE EVENTS | Recalls DailyMed. All Drugs; Human Drugs; Animal Drugs; More ways to search. Advanced Search; Browse Drug Classes ... Label: BRILLIA ADULT- lapine s-100 immune globulin 12 hpc, 30 hpc, 200 hpc pill. Label RSS; Share Bookmark & Share. View Package Photos ..., BRILLIA- lapine s-100 immune globulin 12 hpc, 30 hpc, 50 hpc pill Out of scope - Out of scope for RxNorm and will not receive RxNorm normal forms. Out of scope information includes radiopharmaceuticals, contrast media, herbals, homeopathics, and food., BRILLIA- lapine s-100 immune globulin 12 hpc, 30 hpc, 50 hpc pill Hadaf LLC Disclaimer: This homeopathic product has not been evaluated by the Food and Drug Administration for safety or efficacy. FDA is not aware of scientific evidence to support homeopathy as effective.-----Brillia (Children's) Active ingredients, BRILLIA ADULT- lapine s-100 immune globulin 12 hpc, 30 hpc, 200 hpc pill Hadaf LLC. Disclaimer: This homeopathic product has not been evaluated by the Food and Drug Administration for safety or efficacy. FDA is not aware of scientific evidence to support homeopathy as effective.----- , All content below is taken in its entirety from the CDC Meningococcal ACWY Vaccine Information Statement (VIS): www.cdc.gov/vaccines/hcp/vis/vis-statements/mening.html All content ..., Lapine S-100 immune globulin. How It Works Lapine S-100 are antibodies that bind to the S100B protein to help regulate their activity and reduce the symptoms of hyperactivity and irritability. As a result of the regulating effect of Brillia on the protein S-100, the level of monoamines (dopamine, norepinephrine, serotonin) in different parts of ..., The FDA announced late Thursday that it would issue an emergency use authorization (EUA) for Moderna’s COVID vaccine, bringing our immunization arsenal to a total of two. This vacc..., https://dailymed.nlm.nih.gov/dailymed/labelrss.cfm? setid=680778b9-52d7-562c-e053-2991aa0a72b6 DailyMed will deliver notification of updates and additions to, Lapine S-100 immune globulin. How It Works Lapine S-100 are antibodies that bind specifically to the S100B protein to help regulate impulsivity, mood issues and anxiety. As a result of the regulating effect of Brillia on the protein S-100, the level of monoamines (dopamine, norepinephrine, serotonin) normalizes in different parts of the brain., Do not mix the immune globulin and the hyaluronidase before using. If you need to use 2 infusion sites, use sites on the opposite sides of the body. If you need to use 3 infusion sites, use sites at least 4 inches (10 cm) apart. All other products: It is given as a shot into a muscle or as an infusion into a vein over a period of time., Preferred Substance Name: LAPINE INTERFERON GAMMA IMMUNE GLOBULIN; Synonyms and Mappings. Resources. Inxight Drugs. i. DailyMed Regulated Products. i. NCATS GSRS Full Record. i. ITIS. i. NCBI Taxonomy. i. Note. UNIIs are generated based on scientific identity characteristics using ISO 11238 data elements. UNII availability does not imply any ..., GSRS - National Institutes of Health LAPINE S-100 IMMUNE GLOBULIN is a substance that contains antibodies derived from rabbits. It is used in some homeopathic products to treat various symptoms related to anxiety, stress, irritability, and attention. Learn more about its structure, properties, and sources on this webpage., Label: BRILLIA- lapine s-100 immune globulin 12 hpc, 30 hpc, 50 hpc pill. Label RSS; View Package Photos. Drug Label Info. Safety. Report Adverse Events; FDA Safety Recalls; Presence in Breast Milk; Related Resources. Medline Plus; Clinical Trials; PubMed., BRILLIA HEALTH COUGH CONTROL (lapine bradykinin immune globulin (12c, 30c, 50c), lapine morphine immune globulin (12c, 30c, 50c), lapine histamine immune globulin- 12c, 30c, 50c tablet If this SPL contains inactivated NDCs listed by the FDA initiated compliance action, they will be specified as such., Mechanisms of action of immune globulin. Immunoglobulins are antibodies synthesized by B lymphocytes – plasma cells that can recognize a broad spectrum of specific antigenic determinants, constituting the basis of the humoral immune response. The unique structure of the immunoglobulin molecule ensures the large repertoire of specificities of ...,