Chromogranin a labcorp

Chromogranin A (CGA) is a 439-amino acid protein with a molecular weight of 48 to 60 kDa, depending on glycosylation and phosphorylation status. It is a member of the granin family of proteins and polypeptides. Granins are widespread in endocrine, neuroendocrine, peripheral, and central nervous tissues, where they are found in secretory ...

We would like to show you a description here but the site won't allow us.Chromogranin A is a 68 kD acidic protein which is reported to be widely expressed in neural tissues and in secretory granules of human endocrine cells, for example, parathyroid gland, adrenal medulla, anterior pituitary gland, islet cells of the pancreas and C cells of the thyroid. Chromogranin A expression has been reported in neuroendocrine ... Labcorp test details for Chromogranin A. Elevated CGA levels may be seen in non-NEN malignancies including hepatocellular carcinoma 41 and breast cancer. 42. Circulating CgA is increased in several common, non-neoplastic conditions associated with tissue damage and remolding. 5,43-46 These include: Use. This panel utilizes FDA-cleared assays following the modified 2-tier testing (MTTT) algorithm to aid in the diagnosis of Lyme disease in individuals with clinical signs and symptoms consistent with Lyme disease. Lyme disease should be considered based on the presence of typical signs and symptoms of infection in patients with a history of ...These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. They help us to know which pages are the most and least popular and see how visitors move around the site.LabCorp test: 480061 Components: Cancer Antigen (CA) 125 Cancer Antigen (CA) 125 (Serial Monitor) test cost is between $61.00 and $869.00 ... CA 27.29, Chromogranin A, Cancer Antigen 15-3, Cholesterol, Total, Triglycerides, HDL Cholesterol ...

Well-differentiated neuroendocrine tumours (NETs) are rare, slow-growing tumours. Chromogranin A (CgA) has replaced the 24-h urine collection of 5-hydroxyindoleacetic acid and has become the most important tumour marker in the monitoring of NET during and after treatment and is recommended by the European NeuroEndocrine Tumor Society (Korse et al, 2009; O'Toole et al, 2009).Use serum Chromogranin A (CgA) on B·R·A·H·M·S KRYPTOR instruments as a tool in early detection of prostate cancer transition during monitoring of all your patients under hormonal therapy. The fully automated immunoassay for Chromogranin A is not only indicated in neuroendocrine tumors but also provides a tool to early identify ...Chromogranin A has been used as an immunohistochemical marker for normal and neoplastic neuroendocrine tissues.Elevated plasma concentrations have been demonstrated in patients with tumors of endocrine origin and levels have been shown to correlate with tumor volume.Results for legacy customers who used Gold Connect in the past. Login >. , For IndividualsPatient PortalGet test results, change lab appointments and pay bills. Login > For Healthcare ProfessionalsLabcorp LinkOrder tests, get collection details and view clinical decision-making insights. Login > , Specialty Oncology & Genetics Portals ...Labcorp Patient™ is your partner in managing your health. Our easy and secure Labcorp patient account allows you to get lab results, track your health history, manage appointments and pay bills—all in one place. Thinking about growing your family? Meet the Ovia apps. Get daily, personalized family health support and resources to guide you ...Chromogranin A: 3420100: 3420100: Chromogranin A: 9811-1: No: The CPT codes provided are for general informational purposes only and are based on an interpretation of AMA guidance. It is the sole responsibility of the billing party to determine CPT codes. Any questions regarding coding should be directed to the paying party.Additional Information. B-type natriuretic peptide (BNP), also referred to as brain natriuretic peptide, is a member of a family of structurally similar peptide hormones that includes atrial natriuretic peptide. 1 BNP is a 32-amino-acid peptide that contains a 17-amino-acid ring structure that is formed as the result of an internal disulfide bond.

LIC now ranks second in terms of losing market cap among newly listed IPOs in Asia this year. The Indian government has realised that it disastrously timed the listing of the count...Chromogranin A is a widely used biomarker for the assessment of neuroendocrine neoplasms, especially for the diagnosis and management of those of gastroenteropancreatic origin. Generally, the sensitivity of this nonspecific marker test varies in different neoplasms, ranging from 10% to 100% and its specificity is from 68% to 100% …Specimen Required. Serum separator tube or plain red. Allow serum specimen to clot completely at room temperature. Transfer 1 mL serum to an ARUP standard transport tube. (Min: 0.5 mL) After separation from cells: Room Temperature: 48 hours; Refrigerated: 3 days; Frozen: 3 months.Because new therapeutic options are needed to counter the natural behavior of neuroendocrine tumors, it would also be useful to have a biochemical marker that can be addressed better in the management of these patients. Chromogranin A is currently the most useful biomarker to establish diagnosis and has some utility in predicting disease ...Frequently Asked Questions. Hair Drugs of Abuse Testing (4) Oral Fluid Drug Testing (4) All FAQs for Workplace Drug Testing (8) General (4) Specimen Inquiry (3) Chain of custody image viewing (2) Donor registration (3) User access management (3)

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Chromogranin A, like NSE, is found in all identifiable endocrine cells of the gut ( Facer et al., 1985) ( Fig. 13) and can be detected in human fetal gut before peptides ( Fig. 14 ). Its concentration within a cell fluctuates with the granule content. Unlike NSE, which is often only weakly immunostained in the large bowel, chromogranin A shows ...Labcorp OnDemand is a way to shop and pay for many routine lab tests online. Purchase the lab tests you want - Labcorp OnDemand does not bill your insurance company. Then, following an immediate physician review and order, schedule lab work at your convenience at the Labcorp location nearest you. You'll receive quick, private lab results.Test Preparation Needed? You may be instructed to avoid certain foods and medications prior to this test. (For more details, see the "What is being tested?" section below.) 5-HIAA is a breakdown product of serotonin. The 5-HIAA test measures blood levels to help diagnose and monitors treatment for a carcinoid tumor that produces serotonin.An IgA monoclonal peak >2 g/dL is a major criterion for myeloma. It may be elevated in a wide range of conditions affecting mucosal surfaces, where IgA is largely produced. Some clinically significant IgA deficiencies have concomitant deficiencies of IgG 2 and IgG 4. IgA may be decreased in patients with chronic sinopulmonary disease, in ataxia ...

Use serum Chromogranin A (CgA) on B·R·A·H·M·S KRYPTOR instruments as a tool in early detection of prostate cancer transition during monitoring of all your patients under hormonal therapy. The fully automated immunoassay for Chromogranin A is not only indicated in neuroendocrine tumors but also provides a tool to early identify ... May 27, 2020 · Additional Information. Pancreatic Polypeptide (PP) is a 36 amino acid linear oligopeptide, primary secreted by pancreatic islets of Langerhans cells. 3-6 Its specific role is not well clarified, 7 but it is thought to regulate pancreatic and gastrointestinal secretions 8 and hepatic glycogen levels. 9 PP is generally considered a ... Background: Hepatocellular carcinoma (HCC) is the relevant cause of death in patients with compensated cirrhosis. Alpha-fetoprotein (AFP) is used for screening HCC, with limited success. Aim: We evaluated plasma chromogranin A (CgA) as a marker of HCC. Patients: CgA plasma levels and AFP serum levels were prospectively measured in 30 patients with HCC, 14 with cirrhosis, 79 with chronic ...We would like to show you a description here but the site won't allow us.Order Name CHROMOG A. Test Number: 3803557. Revision Date 12/12/2022. Test Name. Methodology. LOINC Code. Chromogranin A. Thermo Fisher BRAHMS Kryptor. 9811-1.Additional Information. Albumin accounts for approximately 50% of the protein in plasma. 2 The kidney works to prevent the loss of albumin into the urine through active resorption, but a small amount of albumin can be measured in urine of individuals with normal renal function. The prognostic value of consistently elevated albumin levels is ...Pancreastatin - Pancreastatin (PST), also called chromogranin A amide, is a 49-amino acid peptide that was first isolated from porcine pancreas. Pancreastatin is one of a number of biologically active peptides produced by proteolysis of the precursor molecule chromogranin A (CGA). It was first described as an inhibitor of insulin secretion, but since then many different effects have been reported. The neuroendocrine tumors associated with the Zollinger-Ellison syndrome are characterized by elevated rates of gastric HCl secretion and upper gastrointestinal ulcer disease. Gastrin levels >500-600 pg/mL in a patient with basal acid hypersecretion often indicate gastrinoma, but antral G-cell hyperplasia cases can have gastrin levels >500 pg ... Chromogranin A (CgA) is a hydrophilic acidic one-chain peptide containing 439 amino acids, preceded by NH2-terminal 18-amino-acid signal pep-tide; the complete pre-chromogranin A molecule thus encompasses 457 amino acids. It is a member of the chromogranin family that comprises several pro-teins.

Chromogranin A (CgA), present in the chromaffin granules of neuroendocrine cells, is a useful biomarker for the diagnosis of patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs). This study was conducted to investigate the potential role of circulating CgA in monitoring clinical response in …

Here's a printable .pdf that will help you better understand what they mean. Keep in mind, your results are not a diagnosis of any condition. For a full diagnosis, it's best to share your results with a healthcare provider. Please sign in into your account to view this test result interpretation.Serotonin measurement is used in conjunction with urinary 5-hydroxyindoleacetic acid (5-HIAA) and/or serum chromogranin A in the diagnosis of carcinoid syndrome. Carcinoid tumors are slow-growing neuroendocrine tumors derived from enterochromaffin cells that are widely distributed throughout the body. 1-4 Approximately 65% of carcinoid tumors ... Blood. Preparation: No special preparation required. Test Results: 3-4 days. May take longer based on weather, holiday or lab delays. Walk-In Lab is prohibited from selling LabCorp tests to residents in the following states:NY, NJ, RI, MA, MD. The chromogranin A (CgA) test is used as a tumor marker. . It may also be used to detect the presence ... Chromogranin A, LC/MS/MS - Chromogranin-A (CgA) is an acidic glycoprotein expressed in the secretory granules of most normal and neoplastic neuroendocrine (NE) cell types, where it is released together with peptide hormones and biogenic amines.As of 2015, LabCorp customers can find the nearest company location by using the Find a Lab tool found on the company’s website. The LabCorp Find a Lab tool uses the customer’s add...Serotonin test cost max is in Personalabs (Serotonin Blood Test) with price $361.00. This laboratory test is available in 4 online lab test stores. $109.00. Order. Walk-In Lab. Serotonin Blood Test. Covered tests: Serotonin ( LabCorp ) Covered components: Serotonin, Serum. Blacklisted States: NY, NJ, RI.Labcorp test details for Cortisol. Pregnancy, contraceptives, and estrogen therapy give rise to elevated cortisol concentrations. 1 In samples from patients who have been treated with prednisolone, methylprednisolone, or prednisone, falsely elevated concentrations of cortisol may be determined. 1 During metyrapone tests, 11-deoxycortisol levels are elevated. 1 Falsely-elevated cortisol values ...Germany extends travel ban on non-Europeans until at least the end of August. After months of closed borders due to coronavirus, some countries around the world are starting to ope...Chromogranins are acidic secretory glycoproteins with a widespread but specific distribution in neuroendocrine tissues. The chromogranin family is heterogenous, consisting of propeptides such as chromogranin-A, chromogranin-B and secretogranin II, which can either elicit an effect themselves, or serve as precursors to a large number of peptides, which are biologically more active.This report focuses on Chromogranin A (CGA) and some of its derived peptides in critically ill patients, with attention paid to their potential to become biomarkers of severity and actors of defense. First, we studied whether circulating CGA may be a biomarker of outcome in non-selected critically ill patients: CGA concentrations were …

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These cookies allow us to count visits and traffic sources so we can measure and improve the performance of our site. They help us to know which pages are the most and least popular and see how visitors move around the site.LabCorp is a leading provider of diagnostic testing services, offering a wide range of medical tests and screenings. With the advancement of technology, LabCorp has implemented an ...Human immunodeficiency virus (HIV) is the virus that causes acquired immunodeficiency syndrome (AIDS). When a person becomes infected with HIV, the virus attacks and weakens the im...Sept. 28, 2023—Thermo Fisher Scientific announced FDA clearance of its Thermo Scientific Brahms CgA II Kryptor, an automated immunofluorescent assay for the quantitative determination of the concentration of chromogranin A in human serum. The biomarker is to be used in conjunction with other clinical methods as an aid in monitoring disease progression during the course of disease and ...Chromogranin A (CgA) is a hydrophilic acidic one-chain peptide containing 439 amino acids, preceded by NH2-terminal 18-amino-acid signal peptide; the complete pre-chromogranin A molecule thus encompasses 457 amino acids. It is a member of the chromogranin family that comprises several proteins. The CgA gene is a single-copy gene localized in ...Chromogranin A, the protein that is co-stored and co-released with catecholamines from the adrenal medulla, has recently been identified in a variety of human endocrine tissues, both normal and neoplastic. We investigated the secretion of chromogranin A by peptide hormone-producing human tumors in studies of patients with the following ...We report the case of a 50-year-old female patient who presented with symptoms suggestive of a serotonin- secreting neuroendocrine neoplasm. In addition, her serum chromogranin A (CA) level was elevated by more than 8-fold.Clozapine is absorbed rapidly, with peak plasma concentrations occurring within 30 minutes to six hours. Terminal half-life in humans is in the range of 5.5 to 33 hours. Determination of clozapine in plasma is needed to correlate efficacy with plasma concentration. However, pharmacogenomics and coadministration of other agents can complicate ...Human chromogranin A (CgA), a 439 residue-long member of the "granin" secretory protein family, is the precursor of several peptides and polypeptides involved in the regulation of the innate immunity, cardiovascular system, metabolism, angiogenesis, tissue repair, and tumor growth.Despite the many biological activities observed in experimental and preclinical models for CgA and its most ...Chromogranin A, S: 9811-1 . Result ID Test Result Name Result LOINC Value; CGAK: Chromogranin A, S: 9811-1: Test Classification This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent ...Abstract. Chromogranin A (CgA) is a member of the granins, a family of acidic proteins found in abundance in (neuro)endocrine cells (e.g. in chromaffin cells) and in some tumors. Like other granins, CgA has a granulogenic role in secretory granule biogenesis and is stored in these organelles. CgA is partially processed differentially in various ... ….

Serum CGA and urine 5-hydroxyindolacetic acid (5-HIAA) are considered the most useful biochemical markers and are first-line tests in disease surveillance of most patients with carcinoid tumors. (2-4) Serum CGA measurements are used in conjunction with, or alternative to, measurements of serum or whole blood serotonin, urine serotonin and 5 ...COVID-19 Antibody Testing (past infection) COVID-19 antibody test collections (blood draw) are available through our patient service centers, including Labcorp at Walgreens locations. Select 'Routine Labwork' as the service when making an appointment for the COVID-19 antibody test collection. This type of COVID-19 test is for individuals who ...Serotonin measurement is used in conjunction with urinary 5-hydroxyindoleacetic acid (5-HIAA) and/or serum chromogranin A in the diagnosis of carcinoid syndrome. Limitations The majority of gastroenteropancreatic neuroendocrine, carcinoid tumors do not produce elevated whole blood or serum serotonin levels.Chromogranin A, despite a number of limitations, is still the most valuable marker of neuroendocrine tumors (NETs). Granins belong to the family of acidic proteins that constitute a major component of secretory granules of various endocrine and neuroendocrine cells, which are components of both the classical endocrine glands and …A Donor with External Urine Bag. If a donor has an external urine bag, please contact Labcorp Occupational Testing Services (OTS) at 800-833-3934. Our staff will coordinate your urine collection at a facility equipped to provide assistance. Your health and wellbeing is our top priority.The consequences of subclinical thyroid disease (serum TSH 0.1−0.45 μIU/mL or 4.5−10.0 μIU/mL) are minimal and current guidelines recommend against routine treatment of patients with TSH levels in these ranges, but thyroid function tests should be repeated at 6- to 12-month intervals to monitor TSH levels; 8 however, treatment of subclinical …Chromogranin A (CHGA) is an index granin protein critical for biogenesis and exocytotic release of catecholamine storage granules. It is elevated in plasma of patients with sympathetic over-activity and kidney dysfunction. Several CHGA polymorphisms are associated with hypertensive kidney disease.Chromogranin A cell density for the right and left colon expressed as number of cells/mm (2) epithelium or as cell number/field showed a high sensitivity and specificity as a diagnostic marker for LC. Conclusions: Chromogranin A is a common marker for endocrine cells, and the present finding suggests that colonic hormones are involved in the ... Chromogranin a labcorp, Lab tests specific to mast cell activation for suspected MCAS patients should include serum tryptase, serum chromogranin A, plasma histamine, chilled plasma PGD2, stat chilled plasma heparin, chilled urine for PGD2, PGF2a and n-methylhistamine. Tryptase is the most famous mast cell mediator. It is a complex molecule with many functions in the body. It is… Read More »Mast cell mediators ..., Chromogranin A (CgA) is found throughout the diffuse neuroendocrine system and is thought to be the best and most sensitive general marker for the diagnosis and follow-up of NETs, with a sensitivity of 96% and 75% in functioning and non-functioning NETs, respectively, and a specificity of 68-100% ( 7 )., Serotonin, Blood. In conjunction with, or as an alternative to, first-order tests in the differential diagnosis of isolated symptoms suggestive of carcinoid syndrome, in particular flushing (5-hydroxyindoleacetic acid or serum chromogranin A measurements are first-line tests) Second-order test in the follow-up of patients with known or treated ..., Clinical Information. Chromogranin A (CgA) is a 439-amino acid protein with a molecular weight of 48 to 60 kDa, depending on glycosylation and phosphorylation status. It is a member of the granin family of proteins and polypeptides. Granins are widespread in endocrine, neuroendocrine, peripheral, and central nervous tissues, where they are ..., Chromogranin A, due to its primary expression throughout the neuroendocrine system, is a widely accepted biomarker for the assessment of neuro-endocrine tumors. It has been traditionally used in the management of patients with tumors of gastro-enteropancreatic origin. Lately, it has also been implicated in various conditions and diseases, both ..., The aim of this prospective study was to examine whether discontinuation of proton pump inhibitors (PPIs) or replacement by H2-receptor antagonists (H2RA) resulted in a decrease of chromogranin A ..., Please note that the processing of chromogranin A is notably changing around Day 2 at 2:00 (H14) when the patient’s circulatory status no longer requires the two vasopressors. The global immunoblots are decreasing in intensity, and both small and large molecule multimerization is decaying (top panel)., The neuroendocrine tumors associated with the Zollinger-Ellison syndrome are characterized by elevated rates of gastric HCl secretion and upper gastrointestinal ulcer disease. Gastrin levels >500-600 pg/mL in a patient with basal acid hypersecretion often indicate gastrinoma, but antral G-cell hyperplasia cases can have gastrin levels >500 pg ..., Labcorp test details for Chromogranin A 140848: Chromogranin A | Labcorp - The antihypertensive chromogranin a peptide catestatin acts as a novel endocrine/paracrine modulator of cardiac inotropism and lusitropism - PubMed, Order Name CHROMOG A. Test Number: 3803557. Revision Date 12/12/2022. Test Name. Methodology. LOINC Code. Chromogranin A. Thermo Fisher BRAHMS Kryptor. 9811-1., Chromogranin A (CgA) is a protein commonly secreted by neuroendocrine tumor cells. A blood test measures CgA as a tumor marker. In patients treated with somatostatin analogs, CgA tests should be timed carefully with their somatostatin analog treatment. False-positive levels of CgA, due to several issues, including the use of proton pump ... , Test Preparation Needed? You may be instructed to avoid certain foods and medications prior to this test. (For more details, see the “What is being tested?” section below.) 5-HIAA is a breakdown product of serotonin. The 5-HIAA test measures blood levels to help diagnose and monitors treatment for a carcinoid tumor that produces serotonin., The neuroendocrine tumors associated with the Zollinger-Ellison syndrome are characterized by elevated rates of gastric HCl secretion and upper gastrointestinal ulcer disease. Gastrin levels >500-600 pg/mL in a patient with basal acid hypersecretion often indicate gastrinoma, but antral G-cell hyperplasia cases can have gastrin levels >500 pg ... , The majority of gastroenteropancreatic neuroendocrine, carcinoid tumors do not produce elevated whole blood or serum serotonin levels. In most cases, 5-hydroxyindoleacetic acid (5-HIAA) and chromogranin A are superior tests for the assessment of carcinoid syndrome.1-4 In rare instances, a deficiency of aromatic amino acids decarboxylase in …, Dec 12, 2022 · Order Name CHROMOG A. Test Number: 3803557. Revision Date 12/12/2022. Test Name. Methodology. LOINC Code. Chromogranin A. Thermo Fisher BRAHMS Kryptor. 9811-1. , Contact the laboratory prior to specimen collection. This procedure must be scheduled with the laboratory performing the test. The patient should have between two and seven days of sexual abstinence before producing the specimen. This test requires a fresh specimen; therefore, this procedure is available only at sperm testing facilities., COVID-19 Antibody Testing (past infection) COVID-19 antibody test collections (blood draw) are available through our patient service centers, including Labcorp at Walgreens locations. Select 'Routine Labwork' as the service when making an appointment for the COVID-19 antibody test collection. This type of COVID-19 test is for individuals who ..., Want to buy a house with no money down? It's harder to do these days, but not impossible. Get our tips on buying a house with no (or low) money down. Part-Time Money® Make extra mo..., Chromogranin concentration is a prognostic factor for serotonin secreting neuroendocrine tumors originating from the small intestine. Concentration levels of chromogranin often correlate with the size of the tumor and the extent of metastasis. Chromogranin A test is also a potential marker to detect relapse or recurrence of …, Interferencia. Falošné zvýšenie CgA môžu spôsobiť zápaly, renálna insuficiencia, gastritída typu A, liečba inhibítormi protónovej pumpy akortikosteroidmi. Mierne zvýšené koncentrácie nachádzame aj u žien po menopauze. Použiteľnosť pre prax. Diagnostika neuroendokrinných nádorov, kontrola účinnosti terapie., Patients diagnosed with chronic granulomatous disease and/or Job's syndrome may yield a reduced detection of galactomannan. 1 Reduced assay sensitivity may occur in patients receiving concomitant antifungal therapy. 2 Penicillium species, Alternaria species, Paecilomyces species, Geotrichum species, and Histoplasma species have …, Abstract. Background and objectives: Pancreastatin is a derived peptide of chromogranin A (CgA). Pancreastatin has the potential to be a diagnostic and predictive tumor marker in detecting NETs. Methods: Radioimmunoassay tests of pancreastatin and CgA were performed on 103 patient specimens collected at Mount Sinai Medical Center between …, Description: CEA (Carcinoembryonic Antigen) Blood Test (Labcorp) This test measures the level of Carcinoembryonic Antigen (CEA) in the blood. CEA is a protein which is often elevated in people with certain types of cancer . CEA is used as a tumor marker for a variety of cancers including colon, breast, rectum, liver, pancreas, stomach and ovaries., Patients diagnosed with chronic granulomatous disease and/or Job's syndrome may yield a reduced detection of galactomannan. 1 Reduced assay sensitivity may occur in patients receiving concomitant antifungal therapy. 2 Penicillium species, Alternaria species, Paecilomyces species, Geotrichum species, and Histoplasma species have demonstrated reactivity with the monoclonal antibodies used in the ..., Additional Information. Histamine is synthesized from the amino acid L-histidine through the action of the enzyme histidine decarboxylase. 1 This small molecule is primarily produced by mast cells and basophils. These cells are morphologically characterized by numerous, electron dense cytoplasmic granules, which contain histamine and other ..., Laboratory tests search details. Chromogranin A (test) ( remove ) Stores: EconoLabs, LifeExtension, RequestATest, True Health Labs, Walk-In Lab. LabCorp test: 140848 ( …, Chromogranin A is the major catecholamine storage vesicle soluble protein costored and coreleased by exocytosis with catecholamines. Immunoreactive chromogranin A circulates in human plasma, where it may reflect changes in exocytotic sympathoadrenal activity. We measured plasma chromogranin A concen …, Chromogranin A (CgA) is a 439-amino acid protein with a molecular weight of 48 to 60 kDa, depending on glycosylation and phosphorylation status. It is a member of the granin family of proteins and polypeptides. Granins are widespread in endocrine, neuroendocrine, peripheral, and central nervous tissues, where they are found in secretory ..., Labcorp test details for Chromogranin A. Patients & Individuals (Press Get or Space to Abfahren to Landing Page press Urge Down to expand Menu) Patients & Individuals expand menu, Chromogranin A (CGA) belongs to a multifunctional protein family widely distributed in secretory vesicles in neurons and neuroendocrine cells. Within the brain, CGA is localized in neurodegenerative areas associated with reactive microglia. By using cultured rodent microglia, we recently described that CGA induces an activated phenotype and the generation of nitric oxide., Chromogranin A, LC/MS/MS - Chromogranin-A (CgA) is an acidic glycoprotein expressed in the secretory granules of most normal and neoplastic neuroendocrine (NE) cell types, where it is released together with peptide hormones and biogenic amines. Neuroendocrine tumors (NETs) are a form of cancer that differ from other neoplasia in that they …, , Chromogranin A. The most important marker, chromogranin A (CgA), is a constitutive secretory product of most neuroendocrine tumors. Depending on the extent of the disease, plasma CgA is elevated in > 60% of patients. CgA levels may correlate with tumor volumes, but care should be taken in measuring CgA and interpreting the results.